A novel aphrodisiac compound from an orchid that activates nitric oxide synthases
نویسندگان
چکیده
منابع مشابه
Significance of nitric oxide synthases: Lessons from triple nitric oxide synthases null mice.
Nitric oxide (NO) is synthesized by three distinct NO synthases (neuronal, inducible, and endothelial NOSs), all of which are expressed in almost all tissues and organs in humans. The regulatory roles of NOSs in vivo have been investigated in pharmacological studies with non-selective NOS inhibitors. However, the specificity of the inhibitors continues to be an issue of debate, and the authenti...
متن کاملPerspective Series: Nitric Oxide and Nitric Oxide Synthases Nitric Oxide Synthases: Which, Where, How, and Why?
Although nitric oxide (NO) 1 may not modulate all cellular functions and may not be present in all mammalian cells, the sheer volume of publications on the subject might lead one to conclude that this diminutive molecule is both omnipotent and omnipresent in human biology. This series of four Perspective articles, in the current and following issues of The Journal of Clinical Investigation , wi...
متن کاملNitric oxide synthases in mammals.
Nitric oxide is an inorganic free radical gas, of formula *N=O (abbreviated as NO). The discovery in 1987/88 that vascular endothelial cells are able to synthesize NO from L-arginine as a transcellular signal [1-4] was initially received by most biologists with considerable scepticism. By now, however, the existence of the L-arginine:NO pathway has been thoroughly documented and its relevance i...
متن کاملPerspective Series: Nitric Oxide and Nitric Oxide Synthases
Although nitric oxide (NO) 1 may not modulate all cellular functions and may not be present in all mammalian cells, the sheer volume of publications on the subject might lead one to conclude that this diminutive molecule is both omnipotent and omnipresent in human biology. This series of four Perspective articles, in the current and following issues of The Journal of Clinical Investigation , wi...
متن کاملOxygen reduction by nitric-oxide synthases.
Nitric-oxide synthases (NOS, EC 1.14.13.39) are hemeproteins that catalyze oxidation of L-arginine to NOz and L-citrulline. Three main isozymes exist in mammals that are regulated by distinct genes (1–6): a constitutive neuronal NOS (nNOS or NOS I), (7, 8), an endotoxinand cytokine-inducible NOS (iNOS or NOS II) (9, 10), and a constitutive endothelial NOS (eNOS or NOS III) (11). Although NOS ha...
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ژورنال
عنوان ژورنال: International Journal of Impotence Research
سال: 2013
ISSN: 0955-9930,1476-5489
DOI: 10.1038/ijir.2013.18